Do we need to keep playing this tune?

Seghezzo and colleagues1 add to the many other studies that report that 2 doses of dexamethasone and 5 to 7 days of prednisone or prednisolone therapy are associated with no detected difference in relapse or readmission. The implication of that study is that 2 doses of 0.6 mg/kg of dexamethasone (equivalent to 3 mg/kg of prednisolone from standard corticosteroid equivalency tables) matches the efficacy of 5 to 7 days of 1 or 2 mg/kg of prednisone or prednisolone. However, the absence of a placebo in this and other studies cannot distinguish equal efficacy from equal inefficacy.

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