Anaphylaxis and severe immune hemolytic anemia during the course of desensitization with carboplatin

Platinum salts are one of the most frequent cytostatic agents involved in drug hypersensitivity.1 Drug desensitization may enable continuation of therapy for disease control.2 The approach consists of giving incremental doses of the drug by the intravenous route until the therapeutic dose is reached. A transitory desensitization is induced, although release of mast-cell mediators may still occur and require the administration of antihistamines and other drugs.3

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