The serotonin transporter 5-HTTLPR polymorphism and the risk for insomnia: a non-replication

In the June 2014 issue of Sleep Medicine, Huang et al. (2014) reported a genetic association study investigating the effect of 5-HTTLPR on insomnia [1]. In line with previous findings [2], results demonstrated that the short allele is associated with a higher insomnia risk relative to the long allele. The authors further revealed that an interaction between 5-HTTLPR and stress may contribute to this relationship which corresponds with earlier findings on subjective sleep quality [3].

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