Retropharyngeal Nodes in Treatment Deintensification

Treatment deintensification of human papillomavirus (HPV) associated oropharyngeal squamous cell cancer (OPSCC) is a topic of active debate. It is well recognized that HPV-associated OPSCC has unique tumor biological characteristics, reflected by a high propensity for nodal involvement and yet more favorable outcomes compared with HPV-negative OPSCC, with significantly improved overall survival and a reduced risk of recurrence. Because patients with HPV-associated OPSCC are often younger (

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