Πέμπτη 31 Αυγούστου 2017

Mesenchymal Stromal Cell Therapy: After the Gold Rush.

No abstract available

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Long-term Functioning of Allogeneic Islets in Subcutaneous Tissue Pretreated with a Novel Cyclic Peptide without Immunosuppressive Medication.

Background: There exists a need for a minimally invasive method of islet transplantation without immunosuppressive drugs for the treatment of type 1 diabetes. Methods: In diabetic ACI rats, an agarose rod containing the cyclic oligopeptide SEK-1005 (agarose-SEK rod) was implanted at 2 dorsal subcutaneous sites. Then these rods were removed, and 1500 islets isolated from F344 rats were transplanted into each of the pockets. Results: Ten days after implantation of agarose-SEK rods, vascularized pockets were present. Nonfasting blood glucose levels confirmed long-term survival of the allogeneic islet grafts, without immunosuppressive therapy, in 8 of 10 recipients. Flow cytometry and gene expression analyses were performed to investigate the mechanisms underlying graft acceptance. Agarose-SEK rod implantation led to the formation of granulomatous tissue containing regulatory T cells that suppressed immune reactions against the allogeneic islet grafts. Conclusions: These results indicate that the use of an agarose-SEK rod to prevascularize a subcutaneous site may be a useful method for achieving successful allogeneic islet transplantation without immunosuppression. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.

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Proton Pump Inhibitor-related Mortality: Let Us Not Be Dead Wrong

We need to be very wary when research might be misinterpreted easily in ways that might scare patients and physicians away from appropriate medication use.

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Preface to the proceedings of the Workshop on Eosinophils in Allergy and Related Diseases 2016

Publication date: September 2017
Source:Allergology International, Volume 66, Supplement
Author(s): Kohei Yamauchi




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Influence of Parasitic Worm Infections on Allergy Diagnosis in Sub-Saharan Africa

Abstract

Epidemiological studies from Sub-Saharan Africa indicate that allergies are on the rise in this region especially in urban compared to rural areas. This increase has been linked to improved hygiene, lifestyle changes, and lower exposure to pathogens in childhood. Reduced exposure to parasitic worm (helminth) infections and allergy outcomes has been the focus of a number of population studies over the years. Paradoxically, there are parallels in the immune responses to helminths and to allergies. Both conditions are associated with elevated levels of immunoglobulin E, high numbers of T helper 2 cells, eosinophils, and mast cells. These immune parallels have meant that the diagnosis of allergies in parts of the world where helminths are endemic can be hampered. The aim of this review is to examine observations from population studies conducted in Sub-Saharan Africa that demonstrate how helminth infections influence the parameters used to diagnose allergy outcomes in this region. We explore specifically how helminth infections hinder the in vitro diagnosis of allergic sensitization, influence the clinical manifestations of allergy, and also the effect of anthelmintic treatment on allergy outcomes. Advancing our understanding of how helminths influence allergy diagnosis is imperative for the development of improved tools to assess, diagnose, and treat allergic disorders in both helminth-endemic and non-endemic countries worldwide.



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Influence of Parasitic Worm Infections on Allergy Diagnosis in Sub-Saharan Africa

Abstract

Epidemiological studies from Sub-Saharan Africa indicate that allergies are on the rise in this region especially in urban compared to rural areas. This increase has been linked to improved hygiene, lifestyle changes, and lower exposure to pathogens in childhood. Reduced exposure to parasitic worm (helminth) infections and allergy outcomes has been the focus of a number of population studies over the years. Paradoxically, there are parallels in the immune responses to helminths and to allergies. Both conditions are associated with elevated levels of immunoglobulin E, high numbers of T helper 2 cells, eosinophils, and mast cells. These immune parallels have meant that the diagnosis of allergies in parts of the world where helminths are endemic can be hampered. The aim of this review is to examine observations from population studies conducted in Sub-Saharan Africa that demonstrate how helminth infections influence the parameters used to diagnose allergy outcomes in this region. We explore specifically how helminth infections hinder the in vitro diagnosis of allergic sensitization, influence the clinical manifestations of allergy, and also the effect of anthelmintic treatment on allergy outcomes. Advancing our understanding of how helminths influence allergy diagnosis is imperative for the development of improved tools to assess, diagnose, and treat allergic disorders in both helminth-endemic and non-endemic countries worldwide.



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Impact of dysfunction of the facial nerve after superficial parotidectomy: a prospective study

Publication date: Available online 31 August 2017
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): V.E. Prats-Golczer, E. Gonzalez-Cardero, J.A. Exposito-Tirado, E. Montes-Latorre, L.M. Gonzalez-Perez, P. Infante-Cossio
To evaluate the impact of dysfunction of the facial nerve after superficial parotidectomy for pleomorphic adenoma of the superficial lobe, we prospectively analysed the data of 79 patients using the Facial Disability Index (FDI) and the Short-Form 36-Item (SF-36) questionnaires up to 12 months postoperatively. The function of the facial nerve was grading on the House-Brackmann Scale. Results at 1 week and 1, 3, 6, and 12 months were compared with preoperative (baseline) measurement. The maximum reduction in FDI scores coincided with the highest facial paresis values at one week. Physical values on the FDI significantly decreased during the first three months (p=.039 at 3 months) and psychosocial values improved significantly from then onwards (p=.001 at 12 months). At 12 months, there were signs of full recovery compared with the preoperative baseline, and it was even exceeded in some psychosocial items. The SF-36 questionnaire showed no significant differences at any time during the study. The FDI was a useful instrument with which to understand the impact of facial disability and wellbeing associated with physical, social, and emotional aspects after superficial parotidectomy. Unlike the SF-36 questionnaire, the FDI offers clinicians a tool with which to counsel patients and better inform them about the anticipated results of operation before superficial parotidectomy.



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Corrigendum to “New approach to improve the keratinised peri-implant soft tissues in patients with intraoral osteocutaneous reconstruction using a free flap” [Br J Oral Maxillofac Surg 55 (September (7)) (2017) 732–33]

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Publication date: Available online 31 August 2017
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): N. Patel, D. Patel, J. Kwok




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Tympanometric assessment of Eustachian tube function as a prognostic indicator in myringoplasty

Suresh Babu Undavalli, Narayan Hanumanth Rao Kulkarni, Sukrit Bose, Anuradha Ananthaneni

Advanced Arab Academy of Audio-Vestibulogy Journal 2017 4(1):14-18

Aim To determine eustachian tube function in tubo-tympanic type of chronic ear disease and correlate it with pathological changes in middle ear. Objective To ascertain whether eustachian tube function had any demeanor upon the outcome of myringoplasty. Backgound The prevailing interest in the patho-physiology of the eustachian tube has been stimulated by the persistent incidence of middle ear effusion and chronic otitis media. The ongoing sophistication in current middle ear reconstructive surgery has added more dimensions to the study of eustachian tube and its effects in the course of reconstructive middle ear surgery. One of the prime elements accountable for failure of reconstructive middle ear surgery has been tubal dysfunction. Method In the present study eustachian tube function was evaluated in in 30 patients who were undergoing myringoplasty for tubo-tympanic type of chronic suppurative otitis media having central perforation by tuning fork tests, microscopic evaluation of the middle ear mucosa and Impedance audiometry. Results 70% of the myringoplasty cases had good surgical outcome and of the 24 cases that had good eustation tube function 87.5% had successful surgical outcome remaining cases had recurrence of otorrhea. Conclusion The results were validating good eustachain tube function as a criterion for electing cases under middle ear reconstructive surgery and Impedance audiometer assures a superlative means of appraising Eustachain tube function.

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The role of antibiotics in treating secretory otitis media in children aged 2–12 years in an accredited teaching hospital in southeast Asia

Sarmishtha De, Kamal Kachhawa, Arun Gambhir, Rajesh K Jain, Rasmirekha Behera, Sanjay K Diwan, Sanjay Kumar

Advanced Arab Academy of Audio-Vestibulogy Journal 2017 4(1):6-9

Introduction Secretory otitis media (SOM) is the most common clinical condition that can cause conductive deafness, especially among school-going children. The outcomes of hearing loss in children include speech problems, behavioral problems, and poor academic performance. Management of SOM therefore remains crucial. We carried out a comparative study of antibiotics versus surgical therapy for the treatment of SOM. Patients and methods The present study included 50 patients. Detailed history taking with ENT examinations was performed and documented in a validated pro forma. Routine investigations such as complete blood count, urine examination, audiological investigation such as impedance audiometry, etc, were carried out. Observation and results About 70% of the patients presented with symptoms of ear block with mouth breathing. Increased incidence was found in the 2–6 years age group. The present showed that surgery can increase the rate of recovery, shorten the duration of therapy, and prevent the recurrence of SOM compared with treatment with antibiotics. Conclusion Both the treatments have complications associated with them. Large, well-controlled studies can help resolve the risk–benefit ratio by measuring SOM recurrence, functional outcome, quality of life, and long-term outcomes.

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Sound therapy for tinnitus patients

Mohamed I Shabana, Abeir O Dabbous, Ayman M.M. Abdelkarim

Advanced Arab Academy of Audio-Vestibulogy Journal 2017 4(1):1-5

Sound therapy, or use of any sound for the purposes of tinnitus management, is widely accepted as a management tool for tinnitus. Sound therapy have varying goals. Reducing the attention drawn to tinnitus, reducing the loudness of tinnitus, substituting a less disruptive noise. Sound therapy can be achieved with many modalities: Environmental Enrichment, tinnitus maskers, hearing aids and combination instruments such as: Danalogic iFIT Tinnitus, ReSound Live TS, Oticon's Tinnitus "SoundSupport", Phonak's Tinnitus Balance and Widex Zen Fractal Tones. There are other sound devices e.g.: Acoustic Co-ordinated Reset, Neuromodulation, Serenade, Neuromonics, Phase-Out, Phase-shift and tinnitus inhibitory pathway activation. The advantages of sound therapy are: being non-invasive, reduce patient frustration and anxiety, some patients experience residual inhibition and it can facilitate patient's habituation to tinnitus.

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Hearing profile in children with allergic rhinitis

Adekunle Adeyemo, Josephine Eziyi, Yemisi Amusa, Sanyaolu Ameye

Advanced Arab Academy of Audio-Vestibulogy Journal 2017 4(1):10-13

Objective We carried out this study to determine the profile of hearing of children with allergic rhinitis compared with normal controls. Patients and methods Children with allergic rhinitis between the ages of 4 and 16 years attending the Otorhinolaryngology Clinics as well as age-matched and sex-matched controls were recruited into this study. We obtained the participants' bio data, symptoms and duration using a structured interviewer questionnaire. We then carried out a pure tone audiometry on the participants. The degree of hearing loss was determined on the basis of the WHO standard classification. Results We recruited 99 children with clinical evidence of allergic rhinitis and an equal number of healthy controls completed the study. The mean age was 9.19±3.98 years in the test participants and 9.35±4.05 years in the controls, respectively. Mild hearing loss on the right side was more than twice as common among patients, 24 (24.2%), compared with the controls, 11(11.1%). Left-sided mild hearing loss was more than four times more prevalent among patients with allergic rhinitis, 26 (26.3%), compared with the controls, six (6.1%). Hearing threshold worse than 25 dB hearing level in the better-hearing ear was found to be significantly more prevalent among patients compared with the controls. Conclusion We could conclude that hearing is significantly worse in allergic children compared with controls, with disabling hearing loss being more significantly associated with allergic rhinitis.

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Comparison of two hearing aid fitting formulae in improving the patients’ satisfaction with amplification for experienced hearing aid users

Mohamed Shabana, Mona H Selim, Salwa M Abd El-Latif, Mona M Hamdy, Mai M El-Gohary

Advanced Arab Academy of Audio-Vestibulogy Journal 2017 4(1):19-25

Introduction The effectiveness of real word satisfaction is very important for optimal hearing aid (HA) fitting, which can be assessed using self-report questionnaires. The Client Oriented Scale of Improvement (COSI) and Abbreviated Profile of Hearing Aid Benefit (APHAB) are useful tools for assessing the effectiveness of HA in achieving patient satisfaction. Patients and methods This study included 20 hearing-impaired adults. Their hearing thresholds ranged from moderate to moderately severe sensorineural hearing loss and had previous experience with HAs. Their ages ranged from 18 to 60 years, and the mean duration of HA experience was 3.85±5.02 years. Participants were examined in three scheduled sessions: unaided, aided National Acoustics Laboratories-Nonlinear 2 (NAL-NL2), and aided desired sensation level (DSL) v5. Each session was scheduled 2 months after the previous session. Patient satisfaction was assessed using the COSI and APHAB questionnaires for each HA fitting formulae. Results Both formulae have improved patient's five client needs of the COSI; however, NAL-NL2 had better final ability score compared with DSL v5. Using the APHAB questionnaire, both formulae have decreased the listening difficulty score significantly. Using APHAB questionnaire, NAL-NL2 showed significantly less listening difficulty compared with DSL v5 as regards difficulties in ease of communication, broadband noise, and reverberation. However, both formulae did not improve 'aversiveness' conditions. Conclusion Questionnaires are equally important to audiometric tests and should not be underestimated and hence should be relied upon it in HA-fitting verification.

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Will Fitbit’s Sleep Apnea Tracking Actually Work?

fitbitFitbit, the digital health company whose wristbands have become synonymous with the whole activity-tracking movement, is trying to bring its health monitoring game to the next level — by focusing on a sleep disorder that affects millions of Americans.

Read the full story by clicking here.



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Will Fitbit’s Sleep Apnea Tracking Actually Work?

fitbitFitbit, the digital health company whose wristbands have become synonymous with the whole activity-tracking movement, is trying to bring its health monitoring game to the next level — by focusing on a sleep disorder that affects millions of Americans.

Read the full story by clicking here.



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The hydroxyapatite Turkish Delight: a technical note

Abstract

Nasal dorsum augmentation is commonly performed using autologous cartilage grafts, also in the Turkish Delight technique. The aim of this study was to describe a modification of the Turkish Delight technique for dorsal augmentation consisting of small hydroxyapatite-calcium carbonate granules (0.5–1 mm) that were wrapped in layers of oxidized cellulose and glued with 1–2-cm3 fibrin sealant and to compare its utility with that of other techniques. Clinically stable and satisfactory results were achieved in the four cases examined. Cone-beam computerized tomography (CBCT) imaging revealed that there was no degradation of the graft up to 2 years after surgery. The use of a modified Turkish Delight method using hydroxyapatite granules promises to be a valuable option for the correction of nasal dorsum deficiency.



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Tympanometric assessment of Eustachian tube function as a prognostic indicator in myringoplasty

Suresh Babu Undavalli, Narayan Hanumanth Rao Kulkarni, Sukrit Bose, Anuradha Ananthaneni

Advanced Arab Academy of Audio-Vestibulogy Journal 2017 4(1):14-18

Aim To determine eustachian tube function in tubo-tympanic type of chronic ear disease and correlate it with pathological changes in middle ear. Objective To ascertain whether eustachian tube function had any demeanor upon the outcome of myringoplasty. Backgound The prevailing interest in the patho-physiology of the eustachian tube has been stimulated by the persistent incidence of middle ear effusion and chronic otitis media. The ongoing sophistication in current middle ear reconstructive surgery has added more dimensions to the study of eustachian tube and its effects in the course of reconstructive middle ear surgery. One of the prime elements accountable for failure of reconstructive middle ear surgery has been tubal dysfunction. Method In the present study eustachian tube function was evaluated in in 30 patients who were undergoing myringoplasty for tubo-tympanic type of chronic suppurative otitis media having central perforation by tuning fork tests, microscopic evaluation of the middle ear mucosa and Impedance audiometry. Results 70% of the myringoplasty cases had good surgical outcome and of the 24 cases that had good eustation tube function 87.5% had successful surgical outcome remaining cases had recurrence of otorrhea. Conclusion The results were validating good eustachain tube function as a criterion for electing cases under middle ear reconstructive surgery and Impedance audiometer assures a superlative means of appraising Eustachain tube function.

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The role of antibiotics in treating secretory otitis media in children aged 2–12 years in an accredited teaching hospital in southeast Asia

Sarmishtha De, Kamal Kachhawa, Arun Gambhir, Rajesh K Jain, Rasmirekha Behera, Sanjay K Diwan, Sanjay Kumar

Advanced Arab Academy of Audio-Vestibulogy Journal 2017 4(1):6-9

Introduction Secretory otitis media (SOM) is the most common clinical condition that can cause conductive deafness, especially among school-going children. The outcomes of hearing loss in children include speech problems, behavioral problems, and poor academic performance. Management of SOM therefore remains crucial. We carried out a comparative study of antibiotics versus surgical therapy for the treatment of SOM. Patients and methods The present study included 50 patients. Detailed history taking with ENT examinations was performed and documented in a validated pro forma. Routine investigations such as complete blood count, urine examination, audiological investigation such as impedance audiometry, etc, were carried out. Observation and results About 70% of the patients presented with symptoms of ear block with mouth breathing. Increased incidence was found in the 2–6 years age group. The present showed that surgery can increase the rate of recovery, shorten the duration of therapy, and prevent the recurrence of SOM compared with treatment with antibiotics. Conclusion Both the treatments have complications associated with them. Large, well-controlled studies can help resolve the risk–benefit ratio by measuring SOM recurrence, functional outcome, quality of life, and long-term outcomes.

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Sound therapy for tinnitus patients

Mohamed I Shabana, Abeir O Dabbous, Ayman M.M. Abdelkarim

Advanced Arab Academy of Audio-Vestibulogy Journal 2017 4(1):1-5

Sound therapy, or use of any sound for the purposes of tinnitus management, is widely accepted as a management tool for tinnitus. Sound therapy have varying goals. Reducing the attention drawn to tinnitus, reducing the loudness of tinnitus, substituting a less disruptive noise. Sound therapy can be achieved with many modalities: Environmental Enrichment, tinnitus maskers, hearing aids and combination instruments such as: Danalogic iFIT Tinnitus, ReSound Live TS, Oticon's Tinnitus "SoundSupport", Phonak's Tinnitus Balance and Widex Zen Fractal Tones. There are other sound devices e.g.: Acoustic Co-ordinated Reset, Neuromodulation, Serenade, Neuromonics, Phase-Out, Phase-shift and tinnitus inhibitory pathway activation. The advantages of sound therapy are: being non-invasive, reduce patient frustration and anxiety, some patients experience residual inhibition and it can facilitate patient's habituation to tinnitus.

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Hearing profile in children with allergic rhinitis

Adekunle Adeyemo, Josephine Eziyi, Yemisi Amusa, Sanyaolu Ameye

Advanced Arab Academy of Audio-Vestibulogy Journal 2017 4(1):10-13

Objective We carried out this study to determine the profile of hearing of children with allergic rhinitis compared with normal controls. Patients and methods Children with allergic rhinitis between the ages of 4 and 16 years attending the Otorhinolaryngology Clinics as well as age-matched and sex-matched controls were recruited into this study. We obtained the participants' bio data, symptoms and duration using a structured interviewer questionnaire. We then carried out a pure tone audiometry on the participants. The degree of hearing loss was determined on the basis of the WHO standard classification. Results We recruited 99 children with clinical evidence of allergic rhinitis and an equal number of healthy controls completed the study. The mean age was 9.19±3.98 years in the test participants and 9.35±4.05 years in the controls, respectively. Mild hearing loss on the right side was more than twice as common among patients, 24 (24.2%), compared with the controls, 11(11.1%). Left-sided mild hearing loss was more than four times more prevalent among patients with allergic rhinitis, 26 (26.3%), compared with the controls, six (6.1%). Hearing threshold worse than 25 dB hearing level in the better-hearing ear was found to be significantly more prevalent among patients compared with the controls. Conclusion We could conclude that hearing is significantly worse in allergic children compared with controls, with disabling hearing loss being more significantly associated with allergic rhinitis.

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Comparison of two hearing aid fitting formulae in improving the patients’ satisfaction with amplification for experienced hearing aid users

Mohamed Shabana, Mona H Selim, Salwa M Abd El-Latif, Mona M Hamdy, Mai M El-Gohary

Advanced Arab Academy of Audio-Vestibulogy Journal 2017 4(1):19-25

Introduction The effectiveness of real word satisfaction is very important for optimal hearing aid (HA) fitting, which can be assessed using self-report questionnaires. The Client Oriented Scale of Improvement (COSI) and Abbreviated Profile of Hearing Aid Benefit (APHAB) are useful tools for assessing the effectiveness of HA in achieving patient satisfaction. Patients and methods This study included 20 hearing-impaired adults. Their hearing thresholds ranged from moderate to moderately severe sensorineural hearing loss and had previous experience with HAs. Their ages ranged from 18 to 60 years, and the mean duration of HA experience was 3.85±5.02 years. Participants were examined in three scheduled sessions: unaided, aided National Acoustics Laboratories-Nonlinear 2 (NAL-NL2), and aided desired sensation level (DSL) v5. Each session was scheduled 2 months after the previous session. Patient satisfaction was assessed using the COSI and APHAB questionnaires for each HA fitting formulae. Results Both formulae have improved patient's five client needs of the COSI; however, NAL-NL2 had better final ability score compared with DSL v5. Using the APHAB questionnaire, both formulae have decreased the listening difficulty score significantly. Using APHAB questionnaire, NAL-NL2 showed significantly less listening difficulty compared with DSL v5 as regards difficulties in ease of communication, broadband noise, and reverberation. However, both formulae did not improve 'aversiveness' conditions. Conclusion Questionnaires are equally important to audiometric tests and should not be underestimated and hence should be relied upon it in HA-fitting verification.

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The hydroxyapatite Turkish Delight: a technical note

Abstract

Nasal dorsum augmentation is commonly performed using autologous cartilage grafts, also in the Turkish Delight technique. The aim of this study was to describe a modification of the Turkish Delight technique for dorsal augmentation consisting of small hydroxyapatite-calcium carbonate granules (0.5–1 mm) that were wrapped in layers of oxidized cellulose and glued with 1–2-cm3 fibrin sealant and to compare its utility with that of other techniques. Clinically stable and satisfactory results were achieved in the four cases examined. Cone-beam computerized tomography (CBCT) imaging revealed that there was no degradation of the graft up to 2 years after surgery. The use of a modified Turkish Delight method using hydroxyapatite granules promises to be a valuable option for the correction of nasal dorsum deficiency.



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Is voice therapy effective for the treatment of dysphonic patients with benign vocal fold lesions?

S03858146.gif

Publication date: Available online 31 August 2017
Source:Auris Nasus Larynx
Author(s): Makoto Ogawa, Hidenori Inohara
ObjectiveTo update our knowledge regarding the effectiveness of voice therapy for the treatment of vocal disturbance associated with benign vocal fold lesions, including vocal polyps, nodules and cysts, and for determining the utility of voice therapy in treating organic voice disorders, while highlighting problems for the future development of this clinical field.MethodsWe conducted a review of the most recent literature on the therapeutic effects of voice therapy, vocal hygiene education or direct vocal training on vocal quality, the lesion appearance and discomfort felt by patients due to the clinical entity of benign vocal fold mass lesions.ResultsAlthough voice therapy is principally indicated for the treatment of functional dysphonia without any organic abnormalities in the vocal folds, a number of clinicians have attempted to perform voice therapy even in dysphonic patients with benign mass lesions in the vocal folds. The two major possible reasons for the effectiveness of voice therapy on vocal disturbance associated with benign vocal fold lesions are hypothesized to be the regression of lesions and the correction of excessive/inappropriate muscle contraction of the phonatory organs. According to the current literature, a substantial proportion of vocal polyps certainly tend to shrink after voice therapy, but whether or not the regression results from voice therapy, vocal hygiene education or a natural cure is unclear at present due to the lack of controlled studies comparing two groups with and without interventions. Regarding vocal nodules, no studies have investigated the effectiveness of voice therapy using proper experimental methodology. Vocal cysts are difficult to cure by voice therapy without surgical excision according to previous studies. Evidences remains insufficient to support the use of voice therapy against benign vocal fold lesions.ConclusionEvidences at present is therefore still insufficient to support the use of voice therapy for the treatment of benign vocal fold lesions.



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Is voice therapy effective for the treatment of dysphonic patients with benign vocal fold lesions?

S03858146.gif

Publication date: Available online 31 August 2017
Source:Auris Nasus Larynx
Author(s): Makoto Ogawa, Hidenori Inohara
ObjectiveTo update our knowledge regarding the effectiveness of voice therapy for the treatment of vocal disturbance associated with benign vocal fold lesions, including vocal polyps, nodules and cysts, and for determining the utility of voice therapy in treating organic voice disorders, while highlighting problems for the future development of this clinical field.MethodsWe conducted a review of the most recent literature on the therapeutic effects of voice therapy, vocal hygiene education or direct vocal training on vocal quality, the lesion appearance and discomfort felt by patients due to the clinical entity of benign vocal fold mass lesions.ResultsAlthough voice therapy is principally indicated for the treatment of functional dysphonia without any organic abnormalities in the vocal folds, a number of clinicians have attempted to perform voice therapy even in dysphonic patients with benign mass lesions in the vocal folds. The two major possible reasons for the effectiveness of voice therapy on vocal disturbance associated with benign vocal fold lesions are hypothesized to be the regression of lesions and the correction of excessive/inappropriate muscle contraction of the phonatory organs. According to the current literature, a substantial proportion of vocal polyps certainly tend to shrink after voice therapy, but whether or not the regression results from voice therapy, vocal hygiene education or a natural cure is unclear at present due to the lack of controlled studies comparing two groups with and without interventions. Regarding vocal nodules, no studies have investigated the effectiveness of voice therapy using proper experimental methodology. Vocal cysts are difficult to cure by voice therapy without surgical excision according to previous studies. Evidences remains insufficient to support the use of voice therapy against benign vocal fold lesions.ConclusionEvidences at present is therefore still insufficient to support the use of voice therapy for the treatment of benign vocal fold lesions.



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Is voice therapy effective for the treatment of dysphonic patients with benign vocal fold lesions?

S03858146.gif

Publication date: Available online 31 August 2017
Source:Auris Nasus Larynx
Author(s): Makoto Ogawa, Hidenori Inohara
ObjectiveTo update our knowledge regarding the effectiveness of voice therapy for the treatment of vocal disturbance associated with benign vocal fold lesions, including vocal polyps, nodules and cysts, and for determining the utility of voice therapy in treating organic voice disorders, while highlighting problems for the future development of this clinical field.MethodsWe conducted a review of the most recent literature on the therapeutic effects of voice therapy, vocal hygiene education or direct vocal training on vocal quality, the lesion appearance and discomfort felt by patients due to the clinical entity of benign vocal fold mass lesions.ResultsAlthough voice therapy is principally indicated for the treatment of functional dysphonia without any organic abnormalities in the vocal folds, a number of clinicians have attempted to perform voice therapy even in dysphonic patients with benign mass lesions in the vocal folds. The two major possible reasons for the effectiveness of voice therapy on vocal disturbance associated with benign vocal fold lesions are hypothesized to be the regression of lesions and the correction of excessive/inappropriate muscle contraction of the phonatory organs. According to the current literature, a substantial proportion of vocal polyps certainly tend to shrink after voice therapy, but whether or not the regression results from voice therapy, vocal hygiene education or a natural cure is unclear at present due to the lack of controlled studies comparing two groups with and without interventions. Regarding vocal nodules, no studies have investigated the effectiveness of voice therapy using proper experimental methodology. Vocal cysts are difficult to cure by voice therapy without surgical excision according to previous studies. Evidences remains insufficient to support the use of voice therapy against benign vocal fold lesions.ConclusionEvidences at present is therefore still insufficient to support the use of voice therapy for the treatment of benign vocal fold lesions.



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Basal cell carcinoma of the Auricular concha

Mohammad Waheed El-Anwar, Mohamed Salah

Indian Journal of Otology 2017 23(3):200-202

Basal cell carcinoma (BCC) is the most common skin cancer. Eighty percent of BCC affect the facial skin. The important challenge is removing all tumor cells to avoid recurrence because recurrent tumor is more difficult to cure. The current study describes the first surgically removed BCC of the concha and describes its management. A 65-year-old woman presented with left painless fixed conchal swelling proved by punch biopsy to be BCC. This mass was totally removed with 0.5 safety margin with excision of all the conchal cartilage and lower part of ascending ramus of the helix. Postauricular raw area was left to be healed with frequent dressing. Histopathological examination confirmed the diagnosis of BCC and proved free surgical margin. The patient was cosmetically satisfied and symptom free up to date without complication or recurrence. A case of BCC of the conchae was reported and could be safely and completely removed. This directs surgeon attention to BCC as a cause of conchal swelling as an early diagnosis when it is still small allows easy, safe removal without the need for reconstruction.

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Pseudomonas aeruginosa and its sensitivity spectrum in chronic suppurative otitis media: A study from Garhwal hills of Uttarakhand State, India

Deepak Juyal, Munesh Sharma, Vikrant Negi, Rajat Prakash, Neelam Sharma

Indian Journal of Otology 2017 23(3):180-184

Introduction: Chronic suppurative otitis media (CSOM) is a chronic inflammation of the middle ear and mastoid cavity, with recurrent ear discharge through a perforated tympanic membrane. It is a major health problem in developing countries causing serious local damage and life-threatening complications. The advent of sophisticated systemic antibiotics and their irrational use has led to the emergence of multidrug-resistant (MDR) bacterial strains and disease complication in return. Pseudomonas aeruginosa, one of the most common organisms to cause CSOM, is a notorious pathogen and is known for its MDR attribute. Objective: The aim of this study was to know the prevalence of P. aeruginosa among the patients suffering from CSOM, to analyze their antimicrobial susceptibility pattern, and to find out MDR P. aeruginosa strains. Materials and Methods: A total of 571 patients clinically diagnosed of CSOM were enrolled in the study (559 patients with unilateral and 12 with bilateral discharge), and 583 samples were obtained from them. Sample processing and identification was done by standard bacteriological methods. One hundred eighty-seven strains were identified as P. aeruginosa and were subjected to antimicrobial susceptibility testing for 10 different antibiotics categorized into five classes. Results: Of total 583 samples collected, growth was seen in 576 (98.8%) samples. P. aeruginosa strains were isolated from 187 (32.1%) samples. Piperacillin-tazobactam (75.4%), amikacin (74.3%), imipenem (70.6%), and cefepime (69.0%) were found to be the most effective antibiotics. Twenty-nine (15.5%) strains were resistant to all the five classes of antibiotics tested. The rate of resistance to fluoroquinolones (48.7%) was highest, followed by antipseudomonal penicillin (41.7%), and was lowest for carbapenems (29.4%). Conclusion: Knowing the etiological agents of CSOM and their antibiogram is of paramount importance for an efficient treatment and prevention of both disease complications and antimicrobial resistance.

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Speech language development after cochlear implants in prelingual children according to the age of implantation

Alexandre Caixeta Guimarães, Henrique Furlan Pauna, Silvia Badur Curi, Vagner Rodrigues Silva, Alexandre S. M Duarte, Arthur Menino Castilho

Indian Journal of Otology 2017 23(3):185-188

Objectives: The purpose of this article is to evaluate the results regarding speech development of implanted children according to the age of implantation. Materials and Methods: This is a retrospective study with all implanted children at a tertiary hospital from 2003 to 2010. Children were grouped according to the age of the activation of the cochlear implant (CI), gender, and etiology. The degree of oral communication and the speech development using the MacArthur-Bates scale were evaluated. Results: Fifty-six children were included, 23 of them were activated before 3 years of age and 33 between 3 and 6 years. The average time of CIs use was 66 months with no significant difference between groups. Oral communication and the MacArthur-Bates Communicative Development Inventories were significantly better in children activated before 3 years (P = 0.018). Conclusion: The oral communication and speech development of children implanted before 3 years of age were significantly better than children implanted after 3 years of age.

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Significance of round window niche drilling for cochlear implant surgery

Deepak Dalmia, Sanjaya Kumar Behera

Indian Journal of Otology 2017 23(3):141-145

Aim: The aim of this study is to determine the extent of round window niche (RWN) drilling for optimal visualization of the round window membrane (RWM) during cochlear implant surgery. Materials and Methods: This is a prospective study of 38 candidates between 1 and 8 years for cochlear implant surgery from March 2014 to March 2016. We classified the visibility of RWM and its cover by RWN on the surgical view through the posterior tympanotomy during surgery into four types (1) Type 1 - fully visible, (2) Type 2-2/3rd (75%–99%) of RWM visible, (3) Type 3 - ½–2/3rd (50%–74%) of RWM visible, and (4) Type IV - ¼th–½ (25%–49%) of RWM visible. Extent of drilling of RWN into (1) drilling of anterosuperior and superior lip, (2) drilling of anterosuperior, superior, and posterosuperior lip, (3) drilling of the anterior lip with anterosuperior, superior, and posterosuperior lip, and (4) drilling of the posterior lip with Type III drilling. Results: Type-4 RWN is the most common and Type-1 least common. The extent of drilling most commonly performed was Type IV drilling of anterosuperior, superior, and posterosuperior and anterior and posterior lip of RWN. Conclusion: Sufficient drilling of the bony overhang is essential for complete exposure of RWM for insertion of electrodes without any hindrance.

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Multimodality approach in evaluation of common crus aplasia

Sai Kiran Pendem, Rajeswaran Rangasami, S Sanjeev Mohanty, Prabhu Radhan Radhakrishnan

Indian Journal of Otology 2017 23(3):211-215

Common crus aplsia is a rare congenital anomaly caused due to abnormal reabsorption of neuroectodermal tissue of membranous common crus. Three patients came to the Department of Otorhinolaryngology with the complaints of poor response to sound. Audiometry examination revealed bilateral sensorineural hearing loss. They were referred to radiology department for high resolution computed tomography (HRCT) and magnetic resonance imaging (MRI) temporal bone as a part of preoperative cochlear implant work up. In the present study, we discuss the HRCT and MRI findings helpful in the diagnosis of this rare anomaly in three cases.

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Comparative assessment of grommets with topical intranasal steroid in cases of otitis media with effusion

Sushil Suresh Chavan, Prakash S Nagpure

Indian Journal of Otology 2017 23(3):146-150

Aim: This study of 56 patients is to assess the effectiveness of grommet insertion compared with non-surgical treatment steroids (topical intranasal) in otitis media effusion (OME) cases and study complications related to the grommet and topical intranasal steroid. Material: A total subjects of various age groups attending out patient department of ENT, Kasturba Hospital, MGIMS Sevagram, Hospital, Wardha from june 2013 to august 2015 who meet the inclusion criteria and give their written consent in local language will be included in the study. Method: Comparison of medical and surgical management were done. Medical management include topical intranasal steroids by Mometasone fuorate. The recommended dose for treatment of the nasal symptoms is 1 spray (50 microgram of mometasone furoate in each spray). Recommended duration of spray is 2 to 4 weeks and the stated achievement of effect of spray is approximately 1 to 2 weeks. Surgical management include myringotomy with grommet insertion. Generally, myringotomy is performed in conjunction with the insertion of a polyethylene tube called as grommet. Infants and small children are best managed by performing this procedure under a general anesthetic. In older children and adults, local anesthetic can be used as a single block in posterior canal wall so as it block Arnold"s nerve. Results: From this present study cases of children 10 (47.62%) patients shows improvement and 17 (48.57%) adult patient shows improvement having minimal difference. Similarly failure of treatment in children is 1 (4.76%) complications in 2 (9.52%) and in adult patients 0 (0%) complication in 2 (5.71%) it was not showing significant differences. p value was not significant and showing that the differences in value was not having any level of significance in same group. It is concluded that topical nasal steroids are not so effective as surgical drainage of exudative material (myringotomy). Conclusion: Use of steroid causes nasal irritation and temporary relief only and in some patient causes only retention of fluid. Sometimes grommet retained in tympanic membrane and not extruded out needed manual removel. Beside that Overall results are in the favour of myringotomy with grommet insertion as a better modality.

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Preauricular sinus: A comparative study between different surgical approaches

Ahmed Shaker ElAassar, Mohammad Abd-El Hady, Sherif M Askar, Hazem Said Amer, Mohammad Waheed El-Anwar

Indian Journal of Otology 2017 23(3):193-196

Background: The preauricular sinus is a congenital abnormality of the external ear that is usually asymptomatic. However, if recurrent infection, persistent discharge or abscess formation occurs, complete surgical excision of the sinus is required. Objective: The objective of the study is to compare the long-term results of the preauricular sinus excision by simple sinectomy, microscopic-assisted sinectomy, and supra-auricular approach. Patients and Methods: Patients who had symptomatic preauricular sinus scheduled for surgical excision were randomly categorized into three groups: Group A (sinectomy) for whom preauricular sinus was excised by simple sinectomy using methylene blue; Group B (microscopic-assisted sinectomy) treated by simple sinectomy using the microscopic to follow, dissect out and excise the sinus tract(s); and Group C (supra-auricular approach) treated by the supra-auricular approach. Results: Excisions of 68 preauricular sinuses were carried out in 58 patients. The mean follow-up period was 19.7 months with a range of 9–30 months. The overall recurrence rate was 13.4% (9 cases). The timing of recurrence ranged from 3 to 6 months (3–12 months). The simple sinectomy technique had the highest recurrence rate (28%). The recurrence rate of the microscopic-assisted technique was 15% while the supra-auricular approach had the lowest recurrence rate (3.4%). Conclusion: The supra-auricular approach offers the most favorable outcome for the management of the preauricular sinus.

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Impact of smoking and tobacco addiction on sensorineural hearing loss among normal healthy participants: A cross-sectional cohort study

Balaji Sekher, Vikas Sinha, Sushil G Jha

Indian Journal of Otology 2017 23(3):151-154

Background: Cigarette smoking and tobacco addiction is one of the major health issues worldwide. Tobacco addiction is generally related to health issues such as chronic obstructive pulmonary disease and heart disease hypertension. It is also said that tobacco addiction causes sensorineural hearing loss (SNHL). Aim and Objective: The aim of this study was to show direct correlation between tobacco addiction and SNHL. Materials and Methods: In our study, sixty participants who are addicted to tobacco products at least minimum of 20 years were taken as subjects and matched with age-specific controls who do not have any tobacco addiction. They were asked to undergo basic history taking session, otoscopy, and pure tone audiometry, and results were analyzed. Results: SNHL is more common in tobacco users than the age-specific control group. Conclusion: TObacco addiction (both smoking and tobacco chewing) is associated with increased risk of developing SNHL.

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Left mastoid abscess and right automastoidectomy: Two rare complications of cholesteatoma in a patient

Boon Chye Gan, Mohd Khairi Md Daud

Indian Journal of Otology 2017 23(3):205-207

In most cases of cholesteatoma, patients have a history of occasional scanty ear discharge, tinnitus, and gradual progression of hearing loss that may not bother their daily activities. Therefore, late presentation may occur when this group of patients attributes little importance to the otological symptoms. We report a patient with bilateral cholesteatoma who presented with mastoid abscess on the left ear and automastoidectomy on the right ear. Early detection and management of cholesteatoma is crucial in preventing its complication.

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Evaluation of effects of diabetes mellitus type 2 and hyperlipidemia on hearing

Sandip M Parmar, Pushkar Khare, Meenu Chaudhary

Indian Journal of Otology 2017 23(3):155-161

Background: Age related hearing loss or Presbyacusis may be defined as mid to late onset, bilateral, progressive sensorineural hearing loss, where underlying causes have been excluded. In recent decades there has been a rapid progression in population aging, and with advancing age, chronic diseases and functional impairments become more common. Varying ranges of the prevalence of sensorineural deafness in subjects with diabetes and hyperlipidemia has been reported. The present study was undertaken to determine whether or not diabetes mellitus type 2 and hyperlipidemia induced auditory dysfunction. Materials and Methods: A cross sectional observational study was undertaken which comprised of a total of 200 subjects who were divided in 4 groups, which comprised of 50 control subjects in one group and 150 case subjects in the other 3 groups with presence of diabetes mellitus type 2, hyperlipidemia and those having both diabetes mellitus type 2 and hyperlipidemia. All subjects were evaluated by conducting pure tone audiometry and blood investigations like lipid profile and fasting and postprandial blood sugars. Results: It was observed that hearing loss was more prevalent (62%) and highly significant (P 0.001) as compared to controls in patients with both diabetes mellitus type 2 and hyperlipidemia together. The hearing loss was significantly more for higher frequencies in air and bone conduction thresholds. Conclusion: The prevalence of sensorineural hearing loss was increased in subjects having both diabetes mellitus type 2 and hyperlipidemia and these subjects are at a higher risk of developing sensorineural hearing loss. The hearing loss was progressive, bilateral and affected mainly higher frequencies.

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Comparative study of speech and language development in children with normal hearing and cochlear implant in Iran

Hamed Ahmadi, Hamed Mahmoudian Sani, Gholamreza Farnoosh, Mohammad Reza Mahmoudian Sani

Indian Journal of Otology 2017 23(3):135-140

Today, cochlear implant provides an appropriate opportunity for the development of speech and language in children. In some studies, the age of children at the time of surgery has been stated as the most important factor in the development of speech and language of children after cochlear implant, while in other studies factors, including participation in rehabilitation programs, parental educational level, and lack of other disability have been regarded as key factors in the development of speech and language in these children. This review aims to assess the conducted studies in Iran to identify factors contributing to improving the auditory perception, language, and other skills in children with cochlear implants in comparison to children with normal hearing. The purpose of this study is to review the results of studies conducted on speech and language abilities in children with cochlear implant compared to the normal group in Iran. Directory of Open Access Journals, Google Scholar, PubMed (NLM), LISTA (EBSCO), and Web of Science have been searched. cochlear implants in deaf children before language learning results in the acquisition of speech and language skills in children. Timely detection of hearing impairment, early implantation, duration of hearing, and parental involvement in the rehabilitation process are important factors that affect the development of speech and language. The child's age at the time of implantation, continued participation in rehabilitation programs and the lack of associated problems directly impact the development of auditory perception, speech and language of children with cochlear implant while family education level indirectly impacts this developmental process.

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Effects of nonlinear amplification on differential sensitivity measures in individuals with cochlear hearing impairment

N Devi, G Amritha, Kishore Tanniru

Indian Journal of Otology 2017 23(3):162-167

Objective: The current study focused on exploring the influence of multichannel amplification with wide dynamic range compression (WDRC) on frequency, intensity, and duration discrimination measures at two frequencies in different channels of amplification. Methods: Discrimination measures were performed on twenty ears with moderate flat sensorineural hearing loss using 2-down and 1-up adaptive procedure to achieve 70.7% response on the psychometric function. All stimuli were generated through AUX script and presented using Psycon version 2.18 experimental software and delivered through the speakers oriented at an angle of 0° azimuth. Discrimination measures were performed in both aided and unaided conditions for two pure tone frequencies of 750 and 1500 Hz with 500 ms duration (on/off ramp duration of 80 ms to avoid spectral splatter) presented at a level of 20 dBSL (with reference to the threshold separately in each condition). The responses were recorded through three interval alternative forced choice paradigm with visual feedback. An average of final four reversals out of eight was considered for discrimination threshold estimation. Results and Conclusions: Results revealed a statistically significant deterioration in intensity discrimination and a significant improvement in difference limen for frequency and duration with nonlinear amplification. The deteriorated intensity discrimination scores were explained in perspectives of WDRC acting in amplification device.

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Comparison of myringostapediopexy and malleostapediopexy tympanoplasty with sculptured incus in case of hearing reconstruction in tubotympanic chronic otitis media: A case series

Virendra Pratap Singh, Neha Sharma, Chetan Bansal

Indian Journal of Otology 2017 23(3):189-192

Introduction: Chronic suppurative otitis media (CSOM) is a burden on Indian population due to hearing loss due to deformation of the ossicular chain which needs reconstruction (ossiculoplasty). This study is an attempt to analyze the use of autogenous incus in ossiculoplasty for the same. Aim: The aim of this study is comparison of malleostapediopexy and myringostapediopexy in seventy cases of tubotympanic CSOM. Materials and Methods: Seventy patients with CSOM were operated and tympanoplasty was done. Ossiculoplasty was done using incus interposition as malleostapediopexy and myringostapediopexy and results analyzed. Results: In the present study, the pre- and post-operative air-bone gap values for myringostapediopexy cases were 38.00 ± 6.84 and 27.28 ± 5.12, respectively, and for type malleostapediopexy were 37.95 ± 7.51 and 18.08 ± 4.34, respectively. Statistical Test Used: Unpaired t-test. Conclusion: A better outcome was seen in malleostapediopexy than myringostapediopexy.

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Beck depression Inventory-II in hearing impaired elderly patients: A presbycusis study

Mohammad Hossein Nilforoush, Mahsa Sepehrnejad, Zahra Habibi

Indian Journal of Otology 2017 23(3):168-170

Background and Objective: Hearing impairment is one of the most common sensory deficits in human communities. Recent studies have shown that presbycusis happens earlier than before. Hearing loss due to the aging process, or presbycusis, can cause inability to interpret sounds in speech, decreased ability to communicate and withdrew from society. Therefore these factors may lead to psychological problems such as depression. Since there are few studies evaluating the side effects of presbycusis in Iran, we started the study of depression in presbycusis clients referred to the audiology clinics of Isfahan University of medical science, Isfahan, Iran. Materials and Methods: In this cross-sectional study, the relationship between demographic characteristics and depression was determined. In order to collect information and evaluate depression, Beck Depression Inventory-II (BDI-II) was utilized and conducted on 35 cases. Results: Results indicated that 8.6fcr% had minimal depression, 14.3% with mild, 20.0% moderate depression and 57.1% had severe depression. No significant correlation between age, gender and depression was achieved. Conclusion: Using depression questionnaire such as BDI-II during aural rehabilitation process could be valuable. More complications were found in acceptance of hearing aids in elderly people with depression. Psychological treatment can be suitable while audiological management was accomplished simultaneously for this group.

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Simultaneous labyrinthectomy and cochlear implantation for a case of otosclerosis with intractable vertigo

Joyce Pascal Rozario, Anjali Lepcha, John Mathew

Indian Journal of Otology 2017 23(3):197-199

Stapedotomy, though a common surgical procedure for otosclerosis, if inadequately performed, can cause dreaded complications of vertigo and profound hearing loss. Labyrinthectomy with cochlear implantation can be considered in cases of intractable vertigo, as numerous reports have shown that the cochlea still remains responsive to electrical stimulation postlabyrinthectomy. This report presents a case of otosclerosis, with severe to profound deafness and intractable vertigo poststapedotomy surgery, which was treated with simultaneous labyrinthectomy and cochlear implantation. This patient had good control of vertigo postoperatively and the Dizziness Handicap Index score pre- and post-operative were 80 and 38, respectively, with significant improvement in speech perception.

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Comparison of manual and computer-assisted measurement of cochlear nerve obtained from magnetic resonance imaging

S Jeevakala, A Brintha Therese, Rajeswaran Rangasami

Indian Journal of Otology 2017 23(3):171-175

Objectives: Cochlear implantation of sensorineural hearing loss requires accurate measurement of cochlear nerve (CN). The precise measurement of very small structures can be improved by automated segmentation and measurement. The variability and reproducibility of the computer-assisted measurement were compared with manual measurements. Materials and Methods: The 3D-constructive interference in steady state magnetic resonance imaging (MRI) images of twenty patients who were referred for MRI in the assessment of giddiness/vertigo or fitness for cochlear implant during the period from June 2013 to June 2014 were analyzed. The CN sizes were measured manually by two independent radiologists. The automatic measurements were then performed on the same images, and its correlation and agreement were calculated between automated and manual measurements. Results: The intra-observer correlation coefficients were significantly larger for cross-sectional area (CSA) of CN using automated measurements when compared to manual measurement (intra-observer r: 0.94021 vs. 0.91437). Similarly, the inter-observer correlation for CSA of CN is also higher in automated measurements (inter measurement r: 0.94786 vs. 0.92013). Conclusions: Using computer-assisted CN dimension measurement, the intra- and inter-observer correlation can be improved when compared to manual measurements. The automated measurement can assist the radiologist in eliminating the need for tedious manual tracing and thus, the time and effort for manual segmentation are also significantly reduced.

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Unrare but unfamiliar preauricular pilomatricoma mimicking parotid tumor

Anna Park, Jeong Hwan Choi

Indian Journal of Otology 2017 23(3):203-204

Pilomatricoma is a benign skin tumor arising from the outer root sheath cell of the hair follicle that usually present in the head and neck region. Pilomatricoma usually presents as an asymptomatic, solitary, firm or hard, freely mobile, dermal or subcutaneous nodule, and exhibits no fixation to neighboring tissues and has a cartilage-like hardness. The characteristic image findings are reported as well-defined subcutaneous masses with or without visible calcification. Despite these general clinical characteristics, the preoperative diagnosis-based solely on the clinical examination is often difficult because of various manifestations frequently presented by the tumor.

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Radiological changes in anatomy of temporal bone in cases of unsafe chronic suppurative otitis media: A retrospective study

Vinit Kumar Sharma, Neeraj Prajapati, Rohit Sharma, Zafar Iqbal, Shubham Dadoo

Indian Journal of Otology 2017 23(3):176-179

Introduction: The ability of high-resolution computed tomography (HRCT) to depict the status of structure of the temporal bone represents a major advance in delineating pathology before surgical exploration of ear in cases of unsafe chronic suppurative otitis media (CSOM) or cholesteatoma. Aims and Objectives: The aim of this study was to evaluate the role of HRCT temporal bone in cases of unsafe CSOM and to assess the erosion of various structures in middle ear cleft. Study Design: This was a retrospective analysis. Materials and Methods: Fifty HRCT scans of temporal bone of the patients who were diagnosed as case of unsafe CSOM were selected and analyzed retrospectively. Criterion for inclusion was CSOM with cholesteatoma or granulations or polyp or posterior canal wall sagging or foul smelling discharge. In HRCT scans, 1 mm thickness sections were studied in both axial and coronal planes. Criterion for exclusion was history of previous ear surgery, history suggestive of head injury or skull base trauma in the past or known cases of temporal bone neoplastic pathology. Results: Maximum number of patients belonged to the age group of 21–30 years. Ossicular erosion was the most common (90%) finding followed by scutum erosion (84%). Erosion of sigmoid sinus plate was seen in only one case (2%). Cochlear promontory fistula was seen in none of the computed tomography scans. In ossicular chain, incus was the most common ossicle to be necrosed (92%) followed by malleus (66%). Conclusion: HRCT temporal bone delineates the location and extent of the disease and provides information on anatomical variations and complications.

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Reimplantation of an amputated pinna: A case report and review of literature

Brajpal Singh Tyagi, Sushant Tyagi

Indian Journal of Otology 2017 23(3):208-210

Management of the partial or total amputations of the external ear has always stayed a difficult problem for otolaryngologists and plastic surgeons. For successful reimplantations of these amputations, multidisciplinary approach consisting of aggressive medical therapy with broad-spectrum intravenous antibiotics, anticoagulation, and reperfusion in conjunction with efficient surgical approach is needed. The surgeon's main objective is to obtain the best cosmetic result without damaging the auricular area to allow for subsequent future ear reconstruction in case any failure occurs after replantation. To enhance the survival of a reattached ear segment, Mladick et al. have advocated the use of the retroauricular pocket. This technique involves deepithelialization of the amputated part of the avulsed cartilage, followed by reattachment to the amputation stump and then burial into a retroauricular skin pocket. This increases the surface area of the avulsed segment in contact with surrounding nutrients, maximizing the probability of graft uptake and survival. We have used this technique successfully in our case and found acceptable results with it.

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Basal cell carcinoma of the Auricular concha

Mohammad Waheed El-Anwar, Mohamed Salah

Indian Journal of Otology 2017 23(3):200-202

Basal cell carcinoma (BCC) is the most common skin cancer. Eighty percent of BCC affect the facial skin. The important challenge is removing all tumor cells to avoid recurrence because recurrent tumor is more difficult to cure. The current study describes the first surgically removed BCC of the concha and describes its management. A 65-year-old woman presented with left painless fixed conchal swelling proved by punch biopsy to be BCC. This mass was totally removed with 0.5 safety margin with excision of all the conchal cartilage and lower part of ascending ramus of the helix. Postauricular raw area was left to be healed with frequent dressing. Histopathological examination confirmed the diagnosis of BCC and proved free surgical margin. The patient was cosmetically satisfied and symptom free up to date without complication or recurrence. A case of BCC of the conchae was reported and could be safely and completely removed. This directs surgeon attention to BCC as a cause of conchal swelling as an early diagnosis when it is still small allows easy, safe removal without the need for reconstruction.

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Malnutrition among children having otitis media: A Hospital-based cross-sectional study in Lucknow District

Mahmood Dhahir Al-Mendalawi

Indian Journal of Otology 2017 23(3):216-216



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Basal cell carcinoma of the Auricular concha

Mohammad Waheed El-Anwar, Mohamed Salah

Indian Journal of Otology 2017 23(3):200-202

Basal cell carcinoma (BCC) is the most common skin cancer. Eighty percent of BCC affect the facial skin. The important challenge is removing all tumor cells to avoid recurrence because recurrent tumor is more difficult to cure. The current study describes the first surgically removed BCC of the concha and describes its management. A 65-year-old woman presented with left painless fixed conchal swelling proved by punch biopsy to be BCC. This mass was totally removed with 0.5 safety margin with excision of all the conchal cartilage and lower part of ascending ramus of the helix. Postauricular raw area was left to be healed with frequent dressing. Histopathological examination confirmed the diagnosis of BCC and proved free surgical margin. The patient was cosmetically satisfied and symptom free up to date without complication or recurrence. A case of BCC of the conchae was reported and could be safely and completely removed. This directs surgeon attention to BCC as a cause of conchal swelling as an early diagnosis when it is still small allows easy, safe removal without the need for reconstruction.

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Speech language development after cochlear implants in prelingual children according to the age of implantation

Alexandre Caixeta Guimarães, Henrique Furlan Pauna, Silvia Badur Curi, Vagner Rodrigues Silva, Alexandre S. M Duarte, Arthur Menino Castilho

Indian Journal of Otology 2017 23(3):185-188

Objectives: The purpose of this article is to evaluate the results regarding speech development of implanted children according to the age of implantation. Materials and Methods: This is a retrospective study with all implanted children at a tertiary hospital from 2003 to 2010. Children were grouped according to the age of the activation of the cochlear implant (CI), gender, and etiology. The degree of oral communication and the speech development using the MacArthur-Bates scale were evaluated. Results: Fifty-six children were included, 23 of them were activated before 3 years of age and 33 between 3 and 6 years. The average time of CIs use was 66 months with no significant difference between groups. Oral communication and the MacArthur-Bates Communicative Development Inventories were significantly better in children activated before 3 years (P = 0.018). Conclusion: The oral communication and speech development of children implanted before 3 years of age were significantly better than children implanted after 3 years of age.

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Speech language development after cochlear implants in prelingual children according to the age of implantation

Alexandre Caixeta Guimarães, Henrique Furlan Pauna, Silvia Badur Curi, Vagner Rodrigues Silva, Alexandre S. M Duarte, Arthur Menino Castilho

Indian Journal of Otology 2017 23(3):185-188

Objectives: The purpose of this article is to evaluate the results regarding speech development of implanted children according to the age of implantation. Materials and Methods: This is a retrospective study with all implanted children at a tertiary hospital from 2003 to 2010. Children were grouped according to the age of the activation of the cochlear implant (CI), gender, and etiology. The degree of oral communication and the speech development using the MacArthur-Bates scale were evaluated. Results: Fifty-six children were included, 23 of them were activated before 3 years of age and 33 between 3 and 6 years. The average time of CIs use was 66 months with no significant difference between groups. Oral communication and the MacArthur-Bates Communicative Development Inventories were significantly better in children activated before 3 years (P = 0.018). Conclusion: The oral communication and speech development of children implanted before 3 years of age were significantly better than children implanted after 3 years of age.

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Significance of round window niche drilling for cochlear implant surgery

Deepak Dalmia, Sanjaya Kumar Behera

Indian Journal of Otology 2017 23(3):141-145

Aim: The aim of this study is to determine the extent of round window niche (RWN) drilling for optimal visualization of the round window membrane (RWM) during cochlear implant surgery. Materials and Methods: This is a prospective study of 38 candidates between 1 and 8 years for cochlear implant surgery from March 2014 to March 2016. We classified the visibility of RWM and its cover by RWN on the surgical view through the posterior tympanotomy during surgery into four types (1) Type 1 - fully visible, (2) Type 2-2/3rd (75%–99%) of RWM visible, (3) Type 3 - ½–2/3rd (50%–74%) of RWM visible, and (4) Type IV - ¼th–½ (25%–49%) of RWM visible. Extent of drilling of RWN into (1) drilling of anterosuperior and superior lip, (2) drilling of anterosuperior, superior, and posterosuperior lip, (3) drilling of the anterior lip with anterosuperior, superior, and posterosuperior lip, and (4) drilling of the posterior lip with Type III drilling. Results: Type-4 RWN is the most common and Type-1 least common. The extent of drilling most commonly performed was Type IV drilling of anterosuperior, superior, and posterosuperior and anterior and posterior lip of RWN. Conclusion: Sufficient drilling of the bony overhang is essential for complete exposure of RWM for insertion of electrodes without any hindrance.

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Multimodality approach in evaluation of common crus aplasia

Sai Kiran Pendem, Rajeswaran Rangasami, S Sanjeev Mohanty, Prabhu Radhan Radhakrishnan

Indian Journal of Otology 2017 23(3):211-215

Common crus aplsia is a rare congenital anomaly caused due to abnormal reabsorption of neuroectodermal tissue of membranous common crus. Three patients came to the Department of Otorhinolaryngology with the complaints of poor response to sound. Audiometry examination revealed bilateral sensorineural hearing loss. They were referred to radiology department for high resolution computed tomography (HRCT) and magnetic resonance imaging (MRI) temporal bone as a part of preoperative cochlear implant work up. In the present study, we discuss the HRCT and MRI findings helpful in the diagnosis of this rare anomaly in three cases.

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Comparative assessment of grommets with topical intranasal steroid in cases of otitis media with effusion

Sushil Suresh Chavan, Prakash S Nagpure

Indian Journal of Otology 2017 23(3):146-150

Aim: This study of 56 patients is to assess the effectiveness of grommet insertion compared with non-surgical treatment steroids (topical intranasal) in otitis media effusion (OME) cases and study complications related to the grommet and topical intranasal steroid. Material: A total subjects of various age groups attending out patient department of ENT, Kasturba Hospital, MGIMS Sevagram, Hospital, Wardha from june 2013 to august 2015 who meet the inclusion criteria and give their written consent in local language will be included in the study. Method: Comparison of medical and surgical management were done. Medical management include topical intranasal steroids by Mometasone fuorate. The recommended dose for treatment of the nasal symptoms is 1 spray (50 microgram of mometasone furoate in each spray). Recommended duration of spray is 2 to 4 weeks and the stated achievement of effect of spray is approximately 1 to 2 weeks. Surgical management include myringotomy with grommet insertion. Generally, myringotomy is performed in conjunction with the insertion of a polyethylene tube called as grommet. Infants and small children are best managed by performing this procedure under a general anesthetic. In older children and adults, local anesthetic can be used as a single block in posterior canal wall so as it block Arnold"s nerve. Results: From this present study cases of children 10 (47.62%) patients shows improvement and 17 (48.57%) adult patient shows improvement having minimal difference. Similarly failure of treatment in children is 1 (4.76%) complications in 2 (9.52%) and in adult patients 0 (0%) complication in 2 (5.71%) it was not showing significant differences. p value was not significant and showing that the differences in value was not having any level of significance in same group. It is concluded that topical nasal steroids are not so effective as surgical drainage of exudative material (myringotomy). Conclusion: Use of steroid causes nasal irritation and temporary relief only and in some patient causes only retention of fluid. Sometimes grommet retained in tympanic membrane and not extruded out needed manual removel. Beside that Overall results are in the favour of myringotomy with grommet insertion as a better modality.

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Significance of round window niche drilling for cochlear implant surgery

Deepak Dalmia, Sanjaya Kumar Behera

Indian Journal of Otology 2017 23(3):141-145

Aim: The aim of this study is to determine the extent of round window niche (RWN) drilling for optimal visualization of the round window membrane (RWM) during cochlear implant surgery. Materials and Methods: This is a prospective study of 38 candidates between 1 and 8 years for cochlear implant surgery from March 2014 to March 2016. We classified the visibility of RWM and its cover by RWN on the surgical view through the posterior tympanotomy during surgery into four types (1) Type 1 - fully visible, (2) Type 2-2/3rd (75%–99%) of RWM visible, (3) Type 3 - ½–2/3rd (50%–74%) of RWM visible, and (4) Type IV - ¼th–½ (25%–49%) of RWM visible. Extent of drilling of RWN into (1) drilling of anterosuperior and superior lip, (2) drilling of anterosuperior, superior, and posterosuperior lip, (3) drilling of the anterior lip with anterosuperior, superior, and posterosuperior lip, and (4) drilling of the posterior lip with Type III drilling. Results: Type-4 RWN is the most common and Type-1 least common. The extent of drilling most commonly performed was Type IV drilling of anterosuperior, superior, and posterosuperior and anterior and posterior lip of RWN. Conclusion: Sufficient drilling of the bony overhang is essential for complete exposure of RWM for insertion of electrodes without any hindrance.

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Multimodality approach in evaluation of common crus aplasia

Sai Kiran Pendem, Rajeswaran Rangasami, S Sanjeev Mohanty, Prabhu Radhan Radhakrishnan

Indian Journal of Otology 2017 23(3):211-215

Common crus aplsia is a rare congenital anomaly caused due to abnormal reabsorption of neuroectodermal tissue of membranous common crus. Three patients came to the Department of Otorhinolaryngology with the complaints of poor response to sound. Audiometry examination revealed bilateral sensorineural hearing loss. They were referred to radiology department for high resolution computed tomography (HRCT) and magnetic resonance imaging (MRI) temporal bone as a part of preoperative cochlear implant work up. In the present study, we discuss the HRCT and MRI findings helpful in the diagnosis of this rare anomaly in three cases.

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Preauricular sinus: A comparative study between different surgical approaches

Ahmed Shaker ElAassar, Mohammad Abd-El Hady, Sherif M Askar, Hazem Said Amer, Mohammad Waheed El-Anwar

Indian Journal of Otology 2017 23(3):193-196

Background: The preauricular sinus is a congenital abnormality of the external ear that is usually asymptomatic. However, if recurrent infection, persistent discharge or abscess formation occurs, complete surgical excision of the sinus is required. Objective: The objective of the study is to compare the long-term results of the preauricular sinus excision by simple sinectomy, microscopic-assisted sinectomy, and supra-auricular approach. Patients and Methods: Patients who had symptomatic preauricular sinus scheduled for surgical excision were randomly categorized into three groups: Group A (sinectomy) for whom preauricular sinus was excised by simple sinectomy using methylene blue; Group B (microscopic-assisted sinectomy) treated by simple sinectomy using the microscopic to follow, dissect out and excise the sinus tract(s); and Group C (supra-auricular approach) treated by the supra-auricular approach. Results: Excisions of 68 preauricular sinuses were carried out in 58 patients. The mean follow-up period was 19.7 months with a range of 9–30 months. The overall recurrence rate was 13.4% (9 cases). The timing of recurrence ranged from 3 to 6 months (3–12 months). The simple sinectomy technique had the highest recurrence rate (28%). The recurrence rate of the microscopic-assisted technique was 15% while the supra-auricular approach had the lowest recurrence rate (3.4%). Conclusion: The supra-auricular approach offers the most favorable outcome for the management of the preauricular sinus.

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Comparative assessment of grommets with topical intranasal steroid in cases of otitis media with effusion

Sushil Suresh Chavan, Prakash S Nagpure

Indian Journal of Otology 2017 23(3):146-150

Aim: This study of 56 patients is to assess the effectiveness of grommet insertion compared with non-surgical treatment steroids (topical intranasal) in otitis media effusion (OME) cases and study complications related to the grommet and topical intranasal steroid. Material: A total subjects of various age groups attending out patient department of ENT, Kasturba Hospital, MGIMS Sevagram, Hospital, Wardha from june 2013 to august 2015 who meet the inclusion criteria and give their written consent in local language will be included in the study. Method: Comparison of medical and surgical management were done. Medical management include topical intranasal steroids by Mometasone fuorate. The recommended dose for treatment of the nasal symptoms is 1 spray (50 microgram of mometasone furoate in each spray). Recommended duration of spray is 2 to 4 weeks and the stated achievement of effect of spray is approximately 1 to 2 weeks. Surgical management include myringotomy with grommet insertion. Generally, myringotomy is performed in conjunction with the insertion of a polyethylene tube called as grommet. Infants and small children are best managed by performing this procedure under a general anesthetic. In older children and adults, local anesthetic can be used as a single block in posterior canal wall so as it block Arnold"s nerve. Results: From this present study cases of children 10 (47.62%) patients shows improvement and 17 (48.57%) adult patient shows improvement having minimal difference. Similarly failure of treatment in children is 1 (4.76%) complications in 2 (9.52%) and in adult patients 0 (0%) complication in 2 (5.71%) it was not showing significant differences. p value was not significant and showing that the differences in value was not having any level of significance in same group. It is concluded that topical nasal steroids are not so effective as surgical drainage of exudative material (myringotomy). Conclusion: Use of steroid causes nasal irritation and temporary relief only and in some patient causes only retention of fluid. Sometimes grommet retained in tympanic membrane and not extruded out needed manual removel. Beside that Overall results are in the favour of myringotomy with grommet insertion as a better modality.

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Impact of smoking and tobacco addiction on sensorineural hearing loss among normal healthy participants: A cross-sectional cohort study

Balaji Sekher, Vikas Sinha, Sushil G Jha

Indian Journal of Otology 2017 23(3):151-154

Background: Cigarette smoking and tobacco addiction is one of the major health issues worldwide. Tobacco addiction is generally related to health issues such as chronic obstructive pulmonary disease and heart disease hypertension. It is also said that tobacco addiction causes sensorineural hearing loss (SNHL). Aim and Objective: The aim of this study was to show direct correlation between tobacco addiction and SNHL. Materials and Methods: In our study, sixty participants who are addicted to tobacco products at least minimum of 20 years were taken as subjects and matched with age-specific controls who do not have any tobacco addiction. They were asked to undergo basic history taking session, otoscopy, and pure tone audiometry, and results were analyzed. Results: SNHL is more common in tobacco users than the age-specific control group. Conclusion: TObacco addiction (both smoking and tobacco chewing) is associated with increased risk of developing SNHL.

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Preauricular sinus: A comparative study between different surgical approaches

Ahmed Shaker ElAassar, Mohammad Abd-El Hady, Sherif M Askar, Hazem Said Amer, Mohammad Waheed El-Anwar

Indian Journal of Otology 2017 23(3):193-196

Background: The preauricular sinus is a congenital abnormality of the external ear that is usually asymptomatic. However, if recurrent infection, persistent discharge or abscess formation occurs, complete surgical excision of the sinus is required. Objective: The objective of the study is to compare the long-term results of the preauricular sinus excision by simple sinectomy, microscopic-assisted sinectomy, and supra-auricular approach. Patients and Methods: Patients who had symptomatic preauricular sinus scheduled for surgical excision were randomly categorized into three groups: Group A (sinectomy) for whom preauricular sinus was excised by simple sinectomy using methylene blue; Group B (microscopic-assisted sinectomy) treated by simple sinectomy using the microscopic to follow, dissect out and excise the sinus tract(s); and Group C (supra-auricular approach) treated by the supra-auricular approach. Results: Excisions of 68 preauricular sinuses were carried out in 58 patients. The mean follow-up period was 19.7 months with a range of 9–30 months. The overall recurrence rate was 13.4% (9 cases). The timing of recurrence ranged from 3 to 6 months (3–12 months). The simple sinectomy technique had the highest recurrence rate (28%). The recurrence rate of the microscopic-assisted technique was 15% while the supra-auricular approach had the lowest recurrence rate (3.4%). Conclusion: The supra-auricular approach offers the most favorable outcome for the management of the preauricular sinus.

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Left mastoid abscess and right automastoidectomy: Two rare complications of cholesteatoma in a patient

Boon Chye Gan, Mohd Khairi Md Daud

Indian Journal of Otology 2017 23(3):205-207

In most cases of cholesteatoma, patients have a history of occasional scanty ear discharge, tinnitus, and gradual progression of hearing loss that may not bother their daily activities. Therefore, late presentation may occur when this group of patients attributes little importance to the otological symptoms. We report a patient with bilateral cholesteatoma who presented with mastoid abscess on the left ear and automastoidectomy on the right ear. Early detection and management of cholesteatoma is crucial in preventing its complication.

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Impact of smoking and tobacco addiction on sensorineural hearing loss among normal healthy participants: A cross-sectional cohort study

Balaji Sekher, Vikas Sinha, Sushil G Jha

Indian Journal of Otology 2017 23(3):151-154

Background: Cigarette smoking and tobacco addiction is one of the major health issues worldwide. Tobacco addiction is generally related to health issues such as chronic obstructive pulmonary disease and heart disease hypertension. It is also said that tobacco addiction causes sensorineural hearing loss (SNHL). Aim and Objective: The aim of this study was to show direct correlation between tobacco addiction and SNHL. Materials and Methods: In our study, sixty participants who are addicted to tobacco products at least minimum of 20 years were taken as subjects and matched with age-specific controls who do not have any tobacco addiction. They were asked to undergo basic history taking session, otoscopy, and pure tone audiometry, and results were analyzed. Results: SNHL is more common in tobacco users than the age-specific control group. Conclusion: TObacco addiction (both smoking and tobacco chewing) is associated with increased risk of developing SNHL.

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Left mastoid abscess and right automastoidectomy: Two rare complications of cholesteatoma in a patient

Boon Chye Gan, Mohd Khairi Md Daud

Indian Journal of Otology 2017 23(3):205-207

In most cases of cholesteatoma, patients have a history of occasional scanty ear discharge, tinnitus, and gradual progression of hearing loss that may not bother their daily activities. Therefore, late presentation may occur when this group of patients attributes little importance to the otological symptoms. We report a patient with bilateral cholesteatoma who presented with mastoid abscess on the left ear and automastoidectomy on the right ear. Early detection and management of cholesteatoma is crucial in preventing its complication.

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Radiological changes in anatomy of temporal bone in cases of unsafe chronic suppurative otitis media: A retrospective study

Vinit Kumar Sharma, Neeraj Prajapati, Rohit Sharma, Zafar Iqbal, Shubham Dadoo

Indian Journal of Otology 2017 23(3):176-179

Introduction: The ability of high-resolution computed tomography (HRCT) to depict the status of structure of the temporal bone represents a major advance in delineating pathology before surgical exploration of ear in cases of unsafe chronic suppurative otitis media (CSOM) or cholesteatoma. Aims and Objectives: The aim of this study was to evaluate the role of HRCT temporal bone in cases of unsafe CSOM and to assess the erosion of various structures in middle ear cleft. Study Design: This was a retrospective analysis. Materials and Methods: Fifty HRCT scans of temporal bone of the patients who were diagnosed as case of unsafe CSOM were selected and analyzed retrospectively. Criterion for inclusion was CSOM with cholesteatoma or granulations or polyp or posterior canal wall sagging or foul smelling discharge. In HRCT scans, 1 mm thickness sections were studied in both axial and coronal planes. Criterion for exclusion was history of previous ear surgery, history suggestive of head injury or skull base trauma in the past or known cases of temporal bone neoplastic pathology. Results: Maximum number of patients belonged to the age group of 21–30 years. Ossicular erosion was the most common (90%) finding followed by scutum erosion (84%). Erosion of sigmoid sinus plate was seen in only one case (2%). Cochlear promontory fistula was seen in none of the computed tomography scans. In ossicular chain, incus was the most common ossicle to be necrosed (92%) followed by malleus (66%). Conclusion: HRCT temporal bone delineates the location and extent of the disease and provides information on anatomical variations and complications.

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Reimplantation of an amputated pinna: A case report and review of literature

Brajpal Singh Tyagi, Sushant Tyagi

Indian Journal of Otology 2017 23(3):208-210

Management of the partial or total amputations of the external ear has always stayed a difficult problem for otolaryngologists and plastic surgeons. For successful reimplantations of these amputations, multidisciplinary approach consisting of aggressive medical therapy with broad-spectrum intravenous antibiotics, anticoagulation, and reperfusion in conjunction with efficient surgical approach is needed. The surgeon's main objective is to obtain the best cosmetic result without damaging the auricular area to allow for subsequent future ear reconstruction in case any failure occurs after replantation. To enhance the survival of a reattached ear segment, Mladick et al. have advocated the use of the retroauricular pocket. This technique involves deepithelialization of the amputated part of the avulsed cartilage, followed by reattachment to the amputation stump and then burial into a retroauricular skin pocket. This increases the surface area of the avulsed segment in contact with surrounding nutrients, maximizing the probability of graft uptake and survival. We have used this technique successfully in our case and found acceptable results with it.

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Evaluation of effects of diabetes mellitus type 2 and hyperlipidemia on hearing

Sandip M Parmar, Pushkar Khare, Meenu Chaudhary

Indian Journal of Otology 2017 23(3):155-161

Background: Age related hearing loss or Presbyacusis may be defined as mid to late onset, bilateral, progressive sensorineural hearing loss, where underlying causes have been excluded. In recent decades there has been a rapid progression in population aging, and with advancing age, chronic diseases and functional impairments become more common. Varying ranges of the prevalence of sensorineural deafness in subjects with diabetes and hyperlipidemia has been reported. The present study was undertaken to determine whether or not diabetes mellitus type 2 and hyperlipidemia induced auditory dysfunction. Materials and Methods: A cross sectional observational study was undertaken which comprised of a total of 200 subjects who were divided in 4 groups, which comprised of 50 control subjects in one group and 150 case subjects in the other 3 groups with presence of diabetes mellitus type 2, hyperlipidemia and those having both diabetes mellitus type 2 and hyperlipidemia. All subjects were evaluated by conducting pure tone audiometry and blood investigations like lipid profile and fasting and postprandial blood sugars. Results: It was observed that hearing loss was more prevalent (62%) and highly significant (P 0.001) as compared to controls in patients with both diabetes mellitus type 2 and hyperlipidemia together. The hearing loss was significantly more for higher frequencies in air and bone conduction thresholds. Conclusion: The prevalence of sensorineural hearing loss was increased in subjects having both diabetes mellitus type 2 and hyperlipidemia and these subjects are at a higher risk of developing sensorineural hearing loss. The hearing loss was progressive, bilateral and affected mainly higher frequencies.

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Evaluation of effects of diabetes mellitus type 2 and hyperlipidemia on hearing

Sandip M Parmar, Pushkar Khare, Meenu Chaudhary

Indian Journal of Otology 2017 23(3):155-161

Background: Age related hearing loss or Presbyacusis may be defined as mid to late onset, bilateral, progressive sensorineural hearing loss, where underlying causes have been excluded. In recent decades there has been a rapid progression in population aging, and with advancing age, chronic diseases and functional impairments become more common. Varying ranges of the prevalence of sensorineural deafness in subjects with diabetes and hyperlipidemia has been reported. The present study was undertaken to determine whether or not diabetes mellitus type 2 and hyperlipidemia induced auditory dysfunction. Materials and Methods: A cross sectional observational study was undertaken which comprised of a total of 200 subjects who were divided in 4 groups, which comprised of 50 control subjects in one group and 150 case subjects in the other 3 groups with presence of diabetes mellitus type 2, hyperlipidemia and those having both diabetes mellitus type 2 and hyperlipidemia. All subjects were evaluated by conducting pure tone audiometry and blood investigations like lipid profile and fasting and postprandial blood sugars. Results: It was observed that hearing loss was more prevalent (62%) and highly significant (P 0.001) as compared to controls in patients with both diabetes mellitus type 2 and hyperlipidemia together. The hearing loss was significantly more for higher frequencies in air and bone conduction thresholds. Conclusion: The prevalence of sensorineural hearing loss was increased in subjects having both diabetes mellitus type 2 and hyperlipidemia and these subjects are at a higher risk of developing sensorineural hearing loss. The hearing loss was progressive, bilateral and affected mainly higher frequencies.

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Comparative study of speech and language development in children with normal hearing and cochlear implant in Iran

Hamed Ahmadi, Hamed Mahmoudian Sani, Gholamreza Farnoosh, Mohammad Reza Mahmoudian Sani

Indian Journal of Otology 2017 23(3):135-140

Today, cochlear implant provides an appropriate opportunity for the development of speech and language in children. In some studies, the age of children at the time of surgery has been stated as the most important factor in the development of speech and language of children after cochlear implant, while in other studies factors, including participation in rehabilitation programs, parental educational level, and lack of other disability have been regarded as key factors in the development of speech and language in these children. This review aims to assess the conducted studies in Iran to identify factors contributing to improving the auditory perception, language, and other skills in children with cochlear implants in comparison to children with normal hearing. The purpose of this study is to review the results of studies conducted on speech and language abilities in children with cochlear implant compared to the normal group in Iran. Directory of Open Access Journals, Google Scholar, PubMed (NLM), LISTA (EBSCO), and Web of Science have been searched. cochlear implants in deaf children before language learning results in the acquisition of speech and language skills in children. Timely detection of hearing impairment, early implantation, duration of hearing, and parental involvement in the rehabilitation process are important factors that affect the development of speech and language. The child's age at the time of implantation, continued participation in rehabilitation programs and the lack of associated problems directly impact the development of auditory perception, speech and language of children with cochlear implant while family education level indirectly impacts this developmental process.

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Comparative study of speech and language development in children with normal hearing and cochlear implant in Iran

Hamed Ahmadi, Hamed Mahmoudian Sani, Gholamreza Farnoosh, Mohammad Reza Mahmoudian Sani

Indian Journal of Otology 2017 23(3):135-140

Today, cochlear implant provides an appropriate opportunity for the development of speech and language in children. In some studies, the age of children at the time of surgery has been stated as the most important factor in the development of speech and language of children after cochlear implant, while in other studies factors, including participation in rehabilitation programs, parental educational level, and lack of other disability have been regarded as key factors in the development of speech and language in these children. This review aims to assess the conducted studies in Iran to identify factors contributing to improving the auditory perception, language, and other skills in children with cochlear implants in comparison to children with normal hearing. The purpose of this study is to review the results of studies conducted on speech and language abilities in children with cochlear implant compared to the normal group in Iran. Directory of Open Access Journals, Google Scholar, PubMed (NLM), LISTA (EBSCO), and Web of Science have been searched. cochlear implants in deaf children before language learning results in the acquisition of speech and language skills in children. Timely detection of hearing impairment, early implantation, duration of hearing, and parental involvement in the rehabilitation process are important factors that affect the development of speech and language. The child's age at the time of implantation, continued participation in rehabilitation programs and the lack of associated problems directly impact the development of auditory perception, speech and language of children with cochlear implant while family education level indirectly impacts this developmental process.

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Effects of nonlinear amplification on differential sensitivity measures in individuals with cochlear hearing impairment

N Devi, G Amritha, Kishore Tanniru

Indian Journal of Otology 2017 23(3):162-167

Objective: The current study focused on exploring the influence of multichannel amplification with wide dynamic range compression (WDRC) on frequency, intensity, and duration discrimination measures at two frequencies in different channels of amplification. Methods: Discrimination measures were performed on twenty ears with moderate flat sensorineural hearing loss using 2-down and 1-up adaptive procedure to achieve 70.7% response on the psychometric function. All stimuli were generated through AUX script and presented using Psycon version 2.18 experimental software and delivered through the speakers oriented at an angle of 0° azimuth. Discrimination measures were performed in both aided and unaided conditions for two pure tone frequencies of 750 and 1500 Hz with 500 ms duration (on/off ramp duration of 80 ms to avoid spectral splatter) presented at a level of 20 dBSL (with reference to the threshold separately in each condition). The responses were recorded through three interval alternative forced choice paradigm with visual feedback. An average of final four reversals out of eight was considered for discrimination threshold estimation. Results and Conclusions: Results revealed a statistically significant deterioration in intensity discrimination and a significant improvement in difference limen for frequency and duration with nonlinear amplification. The deteriorated intensity discrimination scores were explained in perspectives of WDRC acting in amplification device.

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Effects of nonlinear amplification on differential sensitivity measures in individuals with cochlear hearing impairment

N Devi, G Amritha, Kishore Tanniru

Indian Journal of Otology 2017 23(3):162-167

Objective: The current study focused on exploring the influence of multichannel amplification with wide dynamic range compression (WDRC) on frequency, intensity, and duration discrimination measures at two frequencies in different channels of amplification. Methods: Discrimination measures were performed on twenty ears with moderate flat sensorineural hearing loss using 2-down and 1-up adaptive procedure to achieve 70.7% response on the psychometric function. All stimuli were generated through AUX script and presented using Psycon version 2.18 experimental software and delivered through the speakers oriented at an angle of 0° azimuth. Discrimination measures were performed in both aided and unaided conditions for two pure tone frequencies of 750 and 1500 Hz with 500 ms duration (on/off ramp duration of 80 ms to avoid spectral splatter) presented at a level of 20 dBSL (with reference to the threshold separately in each condition). The responses were recorded through three interval alternative forced choice paradigm with visual feedback. An average of final four reversals out of eight was considered for discrimination threshold estimation. Results and Conclusions: Results revealed a statistically significant deterioration in intensity discrimination and a significant improvement in difference limen for frequency and duration with nonlinear amplification. The deteriorated intensity discrimination scores were explained in perspectives of WDRC acting in amplification device.

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